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Study Proves Topizole Effective As Malaseb, With Extra Benefits

Mike Moran

So you are a veterinarian? Run-off-your-feet busy no doubt. Here’s a quick rundown on the best treatment for non-specific dermatological skin issues.

The ones where the troubled dog or cat is presented with a skin issue and parasites or mites are quickly ruled out. There is a history of irritated skin and the examination supports that. The skin is inflamed and scaly in patches and the animal is persistently nibbling or scratching so a fungus, yeast or bacteria are the likely culprits. Once a challenging cycle has begun for an animal with such symptoms, it’s important to educate and empower the pet owner. The actions and benefits of Topizole is a good place to start. Recent studies have shown it to be as effective as Malaseb with extra benefits.

{Image – Vet talking to a customer with a cat or dog close by}

Like its counterpart Malaseb, Topizole’s active ingredient is Chlorhexidine 20g/L and Miconazole nitrate 20g/L. With a potent antifungal and proven antimicrobial agent active against gram-positive and gram-negative bacteria that also kills infective spores, this product is highly effective.

An in vitro efficacy trial was carried out by The University of Western Australia comparing Topizole to the reference product Malaseb both unidentified in plain packaging. Findings concluded that both shampoos have a high antimicrobial activity and in a clinical situation the activity of both is expected to be the same.

Overview of the trial:

The trial included (1) minimum inhibitory concentrations test and (2) time kill assay, both completed three times with the following organisms:

  • Staphylococcus pseudintermedius (gram positive bacteria)
  • Pseudomonas aeruginosa (gram negative bacteria)
  • Malassezia pachydermatis (yeast)
  • Malassezia furfur (yeast)
  • Microsporum canis (dermatophyte fungus – otherwise known as ringworm)

(1) Minimum Inhibitory Concentrations

In this trial each of the shampoos were diluted to a series of concentrations ranging from 16% to 0.00001% product. The lowest concentration of product preventing the growth of the test organism was determined as the minimum inhibitory concentration. Both showed highly effective against all organisms and an identical Minimum Inhibitory Concentration at less than a 1:2000 dilution.

(2) Time Kill Assay

This test was carried out to determine how quickly the test organisms were killed when in contact with the two products (using a 10% solution of each). Results for both shampoos showed that the bacteria and fungi were all killed immediately and no organisms were recovered at any time points. There was a moderate loss of viability over time with the yeasts with both shampoos. This is normal and to be expected.

The findings from the research:

So what’s the differentiation? Topizole is more than just an effective germicidal shampoo. It also offers highly desirable benefits as a dog or cat shampoo for the pet owner. A great lather assists in easily dispersing the product evenly across the animal’s skin for maximum penetration, and a lustrous conditioned coat is achieved.

Here’s a quick rundown of the features and benefits of Topizole:


  • Lathers much better than Malaseb
  • No perfume or colourants
  • Effective shampoo base with multifunctional surfactants and conditioners
  • Germicidal ingredients that remove dry scales and degreases skin
  • Available in 250ml, 500ml, 1L and 5L
  • Combined active ingredients Chlorhexidine and Miconazole Nitrate


  • Feels like a regular pet shampoo when applying and is evenly dispersed for a highly effective treatment
  • Minimises reaction to the product or further irritation of the skin’s already disturbed outer barrier
  • Clean and lustrously conditioned coat
  • Designed to treat skin condition AND promote well-cleaned skin reducing the likelihood of reinfection
  • A suitable size for every customer and the option to save money buying in bulk.
  • It works!

Topizole is a number one choice for Veterinarians because it works effectively! Pet owners find the shampoo easy to use, with immediate benefits and quickly praise their Veterinarian when their pet’s skin condition is fast relieved.

{Image – Dog being bathed – lots of soapy lather}

Use: Wet animal, apply and lather with gloved hands or gloved hands and a sponge, leave 10 minutes and rinse thoroughly. Use 50ml for a 30kg medium hair length adult dog and 7-10ml for an adult cat. Twice weekly is ideal to quickly have the skin condition under control, or as you see fit as the prescribing Veterinarian.

Precautions: The recommended precautions for Topizole includes: animal to avoid licking whilst being bathed and avoid inhaling. Do not use inside ears or close to the eyes of the animal. A patch test is recommended for sensitive animals. Skin contact to be avoided by the pet owner.

Formulated by manufacturers with Veterinarian Science qualifications, in a GMP (good manufacturing process) certified facility in Australia; Topizole is registered with APVMA (Australian and Veterinarian Medicine’s Authority). So, you can be rest assured that you are recommending a reputable, top quality product when recommending Topizole.

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